Methanol → Methyl L-ornithine monohydrochloride

HRID 23131

Reaktionsgleichung

Reaktionsgleichung von HRID 23131
[ClH:1].[NH2:2][C@H:3]([C:8]([OH:10])=[O:9])[CH2:4][CH2:5][CH2:6][NH2:7].[CH3:11]O>>[ClH:1].[CH3:11][O:9][C:8](=[O:10])[C@H:3]([CH2:4][CH2:5][CH2:6][NH2:7])[NH2:2]

Komponenten

3

Edukt 2

HCID 887MethanolHCID 76654Ornithine hydrochloride

Produkt 1

HCID 6453904Methyl L-ornithine monohydrochlorideAusbeute 97 %

Versuchsvorschrift

Into a stirred suspension of L-(+)-ornithine hydrochloride (Aldrich) in methanol was bubbled anhydrous hydrochloric acid gas until the solution was saturated. The reaction mixture was capped with a rubber septum and stirring was continued overnight at room temperature. The solvent was then stripped under reduced pressure and the residue triturated with ether. The resulting solid was dried under reduced pressure to afford L-(+)-ornithine methyl ester hydrochloride as a white solid (97% yield).

Aufarbeitung

  1. customwas bubbled anhydrous hydrochloric acid gas until the solution
  2. customThe reaction mixture was capped with a rubber septum
  3. customthe residue triturated with ether
  4. customThe resulting solid was dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-2ce35a539b1e4ded93924c2d28580b37
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06849650B2

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