Thionyl Chloride → HCID 14501734, Verbindung

HRID 231398Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 231398
[F:1][C:2]([F:10])([F:9])[CH2:3][O:4][CH2:5][C:6](O)=[O:7].S(Cl)([Cl:13])=O>C(Cl)(Cl)Cl>[F:1][C:2]([F:10])([F:9])[CH2:3][O:4][CH2:5][C:6]([Cl:13])=[O:7]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 4738453(2,2,2-trifluoroethoxy)acetic acid

Produkt 1

HCID 14501734HCID 14501734, VerbindungAusbeute 54,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a 3-neck 500 ml round-bottom flask equipped with a magnetic stirrer, reflux condenser and addition funnel was added (2,2,2-trifluoroethoxy)acetic acid (30.90 g, 0.196 moles) and 250 ml of chloroform under nitrogen. Thionyl chloride (30.20 g, 0.250 moles) was added dropwise and the solution refluxed for 2 hours. The mixture was then concentrated by distillation of the chloroform and excess thionyl chloride. The remaining yellow oil was distilled in vacuo to give 18.9 g of the product as a colorless oil, bp 40°-48° C./20 mm.

Aufarbeitung

  1. customTo a 3-neck 500 ml round-bottom flask equipped with a magnetic stirrer
  2. temperaturereflux
  3. additioncondenser and addition funnel
  4. temperaturethe solution refluxed for 2 hours
  5. concentrationThe mixture was then concentrated by distillation of the chloroform and excess thionyl chloride
  6. distillationThe remaining yellow oil was distilled in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-40681304b10842c7b07f9c5deebeebed
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04846873

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