Dimethylamine → N,N-dimethyl-(2-pyridyl)acetamide

HRID 231596

Reaktionsgleichung

Reaktionsgleichung von HRID 231596
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([O:10]CC)=O.[CH3:13][NH:14][CH3:15]>CO>[CH3:13][N:14]([CH3:15])[C:8](=[O:10])[CH2:7][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1

Komponenten

4

Edukt 2

HCID 674DimethylamineHCID 75960Ethyl 2-pyridylacetate

Produkt 1

HCID 10678588N,N-dimethyl-(2-pyridyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To 5.0 g of ethyl 2-pyridylacetate dissolved in 25 ml of MeOH was added 20 ml of dimethyl amine. The mixture was heated at 90° in a steel autoclave for 96 hrs. The solvent/amine mixture was allowed to evaporate until a residual oil was obtained. The residual oill was distilled to afford 4.5 g of the desired N,N-dimethyl-(2-pyridyl)acetamide as a free-flowing yellow oil, bp 105°-110°/0.5 mm.

Aufarbeitung

  1. customto evaporate until a residual oil
  2. customwas obtained
  3. distillationThe residual oill was distilled

Quellen und Nachweise

ORD-Eintrag
ord-fbe29130b7af45a0ad8bdbdccc5f2df4
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04847301

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