2-Chloropyrimidine → 3-[4-(Pyrimidin-2-yl)piperazin-1-yl]propane-1,2-diol

HRID 231762Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 231762
[OH:1][CH:2]([CH2:10][OH:11])[CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.Cl[C:13]1[N:18]=[CH:17][CH:16]=[CH:15][N:14]=1>O1CCOCC1>[N:14]1[CH:15]=[CH:16][CH:17]=[N:18][C:13]=1[N:7]1[CH2:8][CH2:9][N:4]([CH2:3][CH:2]([OH:1])[CH2:10][OH:11])[CH2:5][CH2:6]1

Komponenten

4

Edukt 2

HCID 744042-ChloropyrimidineHCID 1110023-(Piperazin-1-yl)propane-1,2-diol

Produkt 1

HCID 200319993-[4-(Pyrimidin-2-yl)piperazin-1-yl]propane-1,2-diol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

Grams 3.2 of 1-(2,3-dihydroxypropyl)piperazine and 1.14 g of 2-chloropyrimidine in 50 ml dioxane were refluxed for two and a half hour. The reaction mixture was then settled and the solution evaporated to dryness. The residue obtained was extracted with hot acetone and filtered to remove all impurities. After resting 1.1 g of 3-[4-(pyrimidin-2-yl)piperazin-1-yl]propane-1,2-diol were separated, which melted at 118°-120° C.

Aufarbeitung

  1. customthe solution evaporated to dryness
  2. customThe residue obtained
  3. extractionwas extracted with hot acetone
  4. filtrationfiltered
  5. customto remove all impurities
  6. customwere separated

Quellen und Nachweise

ORD-Eintrag
ord-25bdf0bbd7a74db187d6766b64822a0d
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04849422

Notizen zur Reaktion

Wird geladen…