Imidazole → HCID 10845857, Verbindung
Reaktionsgleichung
Cl[C:2]1[N:7]=[C:6]([O:8][CH2:9][CH3:10])[CH:5]=[C:4]([CH3:11])[N:3]=1.[NH:12]1[CH:16]=[CH:15][N:14]=[CH:13]1>O1CCCC1>[CH2:9]([O:8][C:6]1[CH:5]=[C:4]([CH3:11])[N:3]=[C:2]([N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)[N:7]=1)[CH3:10]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
In anhydrous tetrahydrofuran, 173 mg of 2-chloro-4-ethoxy-6-methylpyrimidine was substituted with 68 mg of imidazole. The reaction mixture was treated according to the procedure of Example 5 to yield 103 mg of 4-ethoxy-2-(1-imidazolyl)-6-methylpyrimidine, recrystallized from a mixture of n-hexane and ethyl acetate, having a melting point of 115.5°-116° C.
Aufarbeitung
- additionThe reaction mixture was treated
Quellen und Nachweise
- ORD-Eintrag
- ord-ac4276e7b6eb4ada9ae53823912d360d
- Quelldatensatz
- uspto-grants-1989_07
- Patentnummer
- US04849424
Notizen zur Reaktion
Wird geladen…