Potassium Bromide → Ganglioside GM1

HRID 231810

Reaktionsgleichung

Reaktionsgleichung von HRID 231810
[K+].[Br-].CC[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]([NH:24][C@@H:25]([C@@H:95]([OH:113])/[CH:96]=[CH:97]/[CH2:98][CH2:99][CH2:100][CH2:101][CH2:102][CH2:103][CH2:104][CH2:105][CH2:106][CH2:107][CH2:108][CH2:109][CH2:110]CC)[CH2:26][O:27][C@@H:28]1[O:33][C@H:32]([CH2:34][OH:35])[C@@H:31]([O:36][C@@H:37]2[O:42][C@H:41]([CH2:43][OH:44])[C@H:40]([O:45][C@@H:46]3[O:51][C@H:50]([CH2:52][OH:53])[C@H:49]([OH:54])[C@H:48]([O:55][C@@H:56]4[O:61][C@H:60]([CH2:62][OH:63])[C@H:59]([OH:64])[C@H:58]([OH:65])[C@H:57]4[OH:66])[C@H:47]3[NH:67][C:68]([CH3:70])=[O:69])[C@H:39]([O:71][C@@:72]3([C:89]([OH:91])=[O:90])[O:77][C@@H:76]([C@H:78]([OH:83])[C@H:79]([OH:82])[CH2:80][OH:81])[C@H:75]([NH:84][C:85]([CH3:87])=[O:86])[C@@H:74]([OH:88])[CH2:73]3)[C@H:38]2[OH:92])[C@H:30]([OH:93])[C@H:29]1[OH:94])=[O:23]>>[CH3:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]([NH:24][C@H:25]([C@H:95]([OH:113])/[CH:96]=[CH:97]/[CH2:98][CH2:99][CH2:100][CH2:101][CH2:102][CH2:103][CH2:104][CH2:105][CH2:106][CH2:107][CH2:108][CH2:109][CH3:110])[CH2:26][O:27][C@@H:28]1[O:33][C@H:32]([CH2:34][OH:35])[C@@H:31]([O:36][C@@H:37]2[O:42][C@H:41]([CH2:43][OH:44])[C@H:40]([O:45][C@@H:46]3[O:51][C@H:50]([CH2:52][OH:53])[C@H:49]([OH:54])[C@H:48]([O:55][C@@H:56]4[O:61][C@H:60]([CH2:62][OH:63])[C@H:59]([OH:64])[C@H:58]([OH:65])[C@H:57]4[OH:66])[C@H:47]3[NH:67][C:68]([CH3:70])=[O:69])[C@H:39]([O:71][C@@:72]3([C:89]([OH:91])=[O:90])[O:77][C@@H:76]([C@H:78]([OH:83])[C@H:79]([OH:82])[CH2:80][OH:81])[C@H:75]([NH:84][C:85]([CH3:87])=[O:86])[C@@H:74]([OH:88])[CH2:73]3)[C@H:38]2[OH:92])[C@H:30]([OH:93])[C@H:29]1[OH:94])=[O:23]

Komponenten

3

Edukt 2

HCID 253877Potassium BromideHCID 6473724Ganglioside gm1,ammonium salt,bovine

Produkt 1

HCID 9963963Ganglioside GM1

Versuchsvorschrift

IR spectroscopic examination of KBr pellets shows the typical band of the ester at 1750 cm-1. Chromatographic analysis of the product carried out in the same way as in Example 1 shows the presence of a unitary compound with an Rf of 0.72 and the absence of GM1 ganglioside and its internal ester (Rf 0.65 and 0.75, respectively). Hydrolysis with Na2CO2 as described in Example 1 produces the ganglioside GM1.

Quellen und Nachweise

ORD-Eintrag
ord-3af45d8458de4030b711a3514ff74658
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04849413

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