4-Cyclopentylmorpholine → Methyl 1-morpholino-2-oxa-3-aza-bicyclo[4.3.0]non-3-ene-4-carboxylate

HRID 231883

Reaktionsgleichung

[O:1]1[CH2:6][CH2:5][N:4]([CH:7]2[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH2:3][CH2:2]1.Br[CH2:13][C:14](=[N:19][OH:20])[C:15]([O:17][CH3:18])=[O:16]>>[O:1]1[CH2:6][CH2:5][N:4]([C:7]23[CH2:11][CH2:10][CH2:9][CH:8]2[CH2:13][C:14]([C:15]([O:17][CH3:18])=[O:16])=[N:19][O:20]3)[CH2:3][CH2:2]1

Komponenten

Edukt 2

HCID 134280244-Cyclopentylmorpholine

HCID 71339048Methyl 3-bromo-2-(hydroxyimino)propanoate

Produkt 1

HCID 22154614Methyl 1-morpholino-2-oxa-3-aza-bicyclo[4.3.0]non-3-ene-4-carboxylateAusbeute 70,8 %

Versuchsvorschrift

4.6 g (30 mmol) of morpholinocyclopentane are reacted with 1.75 g (10 mmol) of methyl 3-bromohydroxyiminopropionate by following the method of Example 1(a). 1.9 g of a colorless oil are obtained.

Quellen und Nachweise

ORD-Eintrag: ord-5673db6b23e44e349843706667d1b53a
Quelldatensatz: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04849524

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