HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4,6-Dichloro-5-(4-methylphenyl)pyrimidine → 5-(4-Methylphenyl)-4,6-dichloro-2-phenylpyrimidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4,6-Dichloro-5-(4-methylphenyl)pyrimidine | HCID 21979554 | — |
| Edukt | HCID 178418453 | HCID 178418453 | — |
| Lösungsmittel | Diethyl Ether | HCID 3283 | — |
| Produkt | 5-(4-Methylphenyl)-4,6-dichloro-2-phenylpyrimidine | HCID 19689470 | — |
Reaktionsschritte
A solution of 5-(4-methylphenyl)-4,6-dichloropyrimidine in ether is cooled at -30° C., and thereto is added dropwise a 1.8M phenyl lithium/cyclohexane solution. The reaction mixture is treated in the same manner as in Reference Example 20-(1) to give 5-(4-methylphenyl)-4,6-dichloro-2-phenylpyrimidine as crystalline powder.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05728706 |
| Quelldatensatz | uspto-grants-1998_03 |
| ORD ID | ord-92159ddf5fca43a09bd60ede97b3d342 |
| Quellennotiz | uspto-grants-1998_03 |