Triethylamine → HCID 67902445, Verbindung

HRID 232194Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 232194
O=[C:2]([CH2:16][CH2:17][C:18]([O-:20])=[O:19])[C:3]([O:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=1)=[O:4].[CH2:21]([O:28][C:29]([NH:31][C@@H:32]1[CH2:36][O:35][NH:34][C:33]1=[O:37])=[O:30])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[I-].ClC1C=CC=C[N+]=1C.C(N(CC)CC)C>ClCCl>[CH2:21]([O:28][C:29]([NH:31][C@@H:32]1[CH2:36][O:35][N:34]([C:2]2([C:3]([O:5][CH2:6][C:7]3[CH:8]=[CH:9][C:10]([N+:13]([O-:15])=[O:14])=[CH:11][CH:12]=3)=[O:4])[CH2:16][CH2:17][C:18](=[O:19])[O:20]2)[C:33]1=[O:37])=[O:30])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Komponenten

6

Edukt 4

HCID 8471TriethylamineHCID 1670692-Chloro-1-methylpyridinium iodideHCID 14181639HCID 14181639, VerbindungHCID 221664155-[(4-Nitrophenyl)methoxy]-4,5-dioxopentanoate

Produkt 1

HCID 67902445HCID 67902445, VerbindungAusbeute 24,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In 2 ml of dichloromethane were dissolved 85 mg of Compound (1) and 60 mg of (4R)-4-benzyloxycarbonylamino-3-isoxazolidinone. To the solution were added 77 mg of 2-chloro-1-methylpyridinium iodide and 84 μ1 of triethylamine. The mixture was stirred at room temperature for 40 minutes, followed by concentration under reduced pressure. The residue was dissolved in ethyl acetate, followed by conducting workup similar to that in Example 8(a) to give 31 mg of the subject Compound (8).

Aufarbeitung

  1. concentrationfollowed by concentration under reduced pressure
  2. dissolutionThe residue was dissolved in ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-6b85cee173fd463fb5f0a4e470459ca3
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04851422

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