Hydrochloric Acid → 1,2-Diethyl-4-piperidinone

HRID 232274

Reaktionsgleichung

Reaktionsgleichung von HRID 232274
C[Si](C)(C)[O:3][C:4]([CH:6]=[CH2:7])=[CH2:5].[CH2:10]([NH:12][CH2:13][CH2:14][CH3:15])[CH3:11].B(F)(F)F.CCOCC.Cl>C(Cl)Cl>[CH2:10]([N:12]1[CH2:7][CH2:6][C:4](=[O:5])[CH2:3][CH:13]1[CH2:14][CH3:15])[CH3:11]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 8000Boron trifluoride etherateHCID 883981-Propanamine, N-ethyl-HCID 5546572-(Trimethylsiloxy)-1,3-butadiene

Produkt 1

HCID 200313151,2-Diethyl-4-piperidinone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To 100 mL of methylene chloride cooled to 0° C. is added 2-(trimethylsilyloxy)-1,3-butadiene (14.2 g, 0.1 mol), 8.5 g (0.1 mol) of N-ethyl-propanamine, and 14.2 g (0.1 mol) of borontrifluoride etherate. Monitor the reaction by thinlayer chromatography. Upon completion add 1N HCl until gas evolution ceases. Separate the aqueous layer and make it alkaline with 1N NaOH. Extract twice with 100 mL ether and dry over Na2SO4. Filter the drying agent and evaporated the solvent in vacuo to obtain the title compound.

Aufarbeitung

  1. customMonitor the reaction by thinlayer chromatography
  2. customSeparate the aqueous layer
  3. extractionExtract twice with 100 mL ether
  4. dry with materialdry over Na2SO4
  5. filtrationFilter the drying agent
  6. customevaporated the solvent in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-dc7eb3e1a8054954978500e3c6bd556b
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04851526

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