Methanol → 4-[[2-(3,4,5-Trimethoxyphenyl)ethyl](methyl)amino]hexan-3-ol

HRID 232280

Reaktionsgleichung

Reaktionsgleichung von HRID 232280
[CH3:1][NH:2][CH2:3][CH2:4][C:5]1[CH:10]=[C:9](OC)[C:8]([O:13][CH3:14])=[C:7]([O:15][CH3:16])[CH:6]=1.[CH2:17]([CH:19]1[CH:21]([CH2:22][CH3:23])[O:20]1)[CH3:18].[CH3:24][OH:25]>>[CH3:24][O:25][C:9]1[CH:10]=[C:5]([CH2:4][CH2:3][N:2]([CH3:1])[CH:21]([CH2:22][CH3:23])[CH:19]([OH:20])[CH2:17][CH3:18])[CH:6]=[C:7]([O:15][CH3:16])[C:8]=1[O:13][CH3:14]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 1382642,3-DiethyloxiraneHCID 138365N-Methylmescaline

Produkt 1

HCID 200313814-[[2-(3,4,5-Trimethoxyphenyl)ethyl](methyl)amino]hexan-3-ol

Versuchsvorschrift

Combine 22.5 g (0.1 mol) of N-methyl-3,4,5-trimethoxybenzeneethanamine and 10 g (0.1 mol) of 2,3-diethyloxirane in 150 mL of 90% aqueous methanol. Heat the reaction at 50° C. and follow the progress of the reaction by thin-layer chromatography. At the completion of the reaction remove the solvent in vacuo and chromatograph the residue on silica gel to obtain the title compound.

Aufarbeitung

  1. temperatureHeat
  2. customthe reaction at 50° C.
  3. customthe progress of the reaction by thin-layer chromatography
  4. customAt the completion of the reaction remove the solvent in vacuo and chromatograph the residue on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-9557d6b1d5794e29856206cf104fc55c
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04851526

Verknüpfte Notizen

Wird geladen…