HCID 23359035, Verbindung → 2,4-Difluoro-3,6-dimethylaniline

HRID 232652Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 232652
[F:1][C:2]1[C:8]([CH3:9])=[C:7]([F:10])[CH:6]=[C:5]([CH2:11]SC)[C:3]=1[NH2:4]>[Ni].C(O)C>[F:1][C:2]1[C:8]([CH3:9])=[C:7]([F:10])[CH:6]=[C:5]([CH3:11])[C:3]=1[NH2:4]

Komponenten

4

Edukt 1

HCID 23359035HCID 23359035, Verbindung

Produkt 1

HCID 233590392,4-Difluoro-3,6-dimethylanilineAusbeute 84,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel2×

Versuchsvorschrift

To a solution of Raney nickel (50 g) in ethanol (100 ml) is added a solution of 2,4-difluoro-3-methyl-6-methylthiomethylaniline (4.79 g) in ethanol (30 ml) at room temperature with stirring, followed by stirring at room temperature for 30 minutes. The Raney nickel is filtered off and the filtrate is diluted with water, extracted with dichloromethane, and the extract is washed with water and dried. The solvent is distilled off under reduced pressure to give 2,4-difluoro-3,6-dimethylaniline (3.14 g).

Aufarbeitung

  1. stirringby stirring at room temperature for 30 minutes
  2. filtrationThe Raney nickel is filtered off
  3. additionthe filtrate is diluted with water
  4. extractionextracted with dichloromethane
  5. washthe extract is washed with water
  6. customdried
  7. distillationThe solvent is distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-30bbf59b6a494ba79d5c9790d1dd69ef
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05591744

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