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8-nitro-6-{4-[N-methyl-N-(2-phenylethyl)amino]-1-piperidinylcarbonyl}-3,4-dihydrocarbostyril → 8-amino-6-{4-[N-methyl-N-(2-phenylethyl)amino]-1-piperidinylcarbonyl}-3,4-dihydrocarbostyril

HRID 232717
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Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 232717
[N+:1]([C:4]1[CH:5]=[C:6]([C:15]([N:17]2[CH2:22][CH2:21][CH:20]([N:23]([CH3:32])[CH2:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:19][CH2:18]2)=[O:16])[CH:7]=[C:8]2[C:13]=1[NH:12][C:11](=[O:14])[CH2:10][CH2:9]2)([O-])=O>C(O)C.[C].[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([C:15]([N:17]2[CH2:22][CH2:21][CH:20]([N:23]([CH3:32])[CH2:24][CH2:25][C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH2:19][CH2:18]2)=[O:16])[CH:7]=[C:8]2[C:13]=1[NH:12][C:11](=[O:14])[CH2:10][CH2:9]2
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Komponenten

4

Edukt 1

HCID 110591838-nitro-6-{4-[N-methyl-N-(2-phenylethyl)amino]-1-piperidinylcarbonyl}-3,4-dihydrocarbostyril

Produkt 1

HCID 233590718-amino-6-{4-[N-methyl-N-(2-phenylethyl)amino]-1-piperidinylcarbonyl}-3,4-dihydrocarbostyrilAusbeute 98,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

0.5 g of 5% palladium-carbon was suspended in 0 ml of ethanol. Thereto was added 5 g of 8-nitro-6-{4-[N-methyl-N-(2-phenylethyl)amino]-1-piperidinylcarbonyl}-3,4-dihydrocarbostyril. The mixture was subjected to catalytic reduction at 30°-40° C. at normal pressure in a water bath. After the completion of hydrogen absorption, the reaction mixture was filtered to remove the catalyst. The catalyst was washed with ethanol. The filtrate and the washings were mixed. The mixture was subjected to distillation to remove the solvent to obtain 4.6 g of 8-amino-6-{4-[N-methyl-N-(2-phenylethyl)amino]-1-piperidinylcarbonyl}-3,4-dihydrocarbostyril as a white amorphous.

Aufarbeitung

  1. customThe mixture was subjected to catalytic reduction at 30°-40° C. at normal pressure in a water bath
  2. customAfter the completion of hydrogen absorption
  3. filtrationthe reaction mixture was filtered
  4. customto remove the catalyst
  5. washThe catalyst was washed with ethanol
  6. additionThe filtrate and the washings were mixed
  7. distillationThe mixture was subjected to distillation
  8. customto remove the solvent

Quellen und Nachweise

ORD-Eintrag
ord-84378bda3add43f7b376b7ec35f571b4
Quelldatensatz
uspto-grants-1997_01
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05591751

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