Hydrochloric Acid → L-homoalanin-4-yl(methyl)phosphinic acid hydrochloride

HRID 233118

Reaktionsgleichung

Reaktionsgleichung von HRID 233118
C(OC([N:11]1[C@@H:15]([CH2:16][CH2:17][P:18]([O:21]CC)([CH3:20])=[O:19])[C:14](=[O:24])[O:13]C1)=O)C1C=CC=CC=1.[ClH:25]>>[ClH:25].[NH2:11][C@H:15]([C:14]([OH:24])=[O:13])[CH2:16][CH2:17][P:18]([CH3:20])(=[O:19])[OH:21]

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 14596286(4S)-3-benzyloxycarbonyl-4-{2-[ethoxy(methyl)phosphinyl]ethyl}-1,3-oxazolidin-5-one

Produkt 1

HCID 12701464L-homoalanin-4-yl(methyl)phosphinic acid hydrochlorideAusbeute 82,1 %

Versuchsvorschrift

0.50 g (1.4 mmol) of (4S)-3-benzyloxycarbonyl-4-{2-[ethoxy(methyl)phosphinyl]ethyl}-1,3-oxazolidin-5-one (from Example 12) are, as described in DE-A-3,817,956, hydrolyzed by heating in 6N hydrochloric acid. 0.25 g (82.1% of theory) of L-homoalanin-4-yl(methyl)phosphinic acid hydrochloride are obtained as a white solid having a melting point of Mp 202° C. (decomposition).

Quellen und Nachweise

ORD-Eintrag
ord-b0624cfe68d740beaf2791a7ab5ec070
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05591861

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