Benzenesulfonyl chloride → 2-Bromobenzoic acid 2-phenylsulfonylhydrazide

HRID 233132

Reaktionsgleichung

Reaktionsgleichung von HRID 233132
[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([NH:6][NH2:7])=[O:5].[C:12]1([S:18](Cl)(=[O:20])=[O:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>N1C=CC=CC=1>[C:12]1([S:18]([NH:7][NH:6][C:4](=[O:5])[C:3]2[CH:8]=[CH:9][CH:10]=[CH:11][C:2]=2[Br:1])(=[O:20])=[O:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Komponenten

4

Edukt 2

HCID 7369Benzenesulfonyl chlorideHCID 1014602-Bromobenzohydrazide

Produkt 1

HCID 77099642-Bromobenzoic acid 2-phenylsulfonylhydrazide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To a solution of 2-bromobenzoic acid hydrazide (132 g) in pyridine (1.2 L) cooled to about 10 C. with an ice bath, was added benzensulfonyl chloride (78.3 ml). After complete addition, the reaction was stirred at ambient temperature for four hours, and then poured into ice-hydrochloric acid to precipitate a yellow solid, 135 g. The material was recrystallized from isopropanol to yield 125 g of 2-bromobenzoic acid 2-phenylsulfonylhydrazide, m.p.=154°-156° C.

Aufarbeitung

  1. additionAfter complete addition
  2. customto precipitate a yellow solid, 135 g
  3. customThe material was recrystallized from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-4b5577dff231466cacbaf5ed9e5cd0ed
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05591745

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