Cyclohexylthiourea → 7-[2-(Cyclohexylamino)-1,3-thiazol-5-yl]quinazolin-4(3h)-one

HRID 23357

Reaktionsgleichung

Reaktionsgleichung von HRID 23357
Br[CH:2]([C:5]1[CH:14]=[C:13]2[C:8]([C:9](=[O:15])[NH:10][CH:11]=[N:12]2)=[CH:7][CH:6]=1)[CH:3]=O.[CH:16]1([NH:22][C:23]([NH2:25])=[S:24])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>CN(C)C=O>[CH:16]1([NH:22][C:23]2[S:24][C:2]([C:5]3[CH:14]=[C:13]4[C:8]([C:9](=[O:15])[NH:10][CH:11]=[N:12]4)=[CH:7][CH:6]=3)=[CH:3][N:25]=2)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

Komponenten

4

Edukt 2

HCID 1471603CyclohexylthioureaHCID 135531132Bromo-(4-oxo-3,4-dihydro-quinazolin-7-yl)acetaldehyde

Produkt 1

HCID 1354961657-[2-(Cyclohexylamino)-1,3-thiazol-5-yl]quinazolin-4(3h)-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of bromo-(4-oxo-3,4-dihydro-quinazolin-7-yl)acetaldehyde and N-cyclohexylthiourea in dimethylformamide is heated at 70° C. until completion of the reaction (5-12 hours). The mixture is quenched with 10% dimethylamine in ethanol and the solvent is removed under reduced pressured. The crude is purified by chromatography on silica gel to isolate the desired compound.

Aufarbeitung

  1. customThe mixture is quenched with 10% dimethylamine in ethanol
  2. customthe solvent is removed
  3. customThe crude is purified by chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-25238562fd52496693cf85f9c426924f
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06852720B2

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