Pyridine → 5-(4-Fluorophenyl)-3-(2-piperidinyl)pyridine fumarate

HRID 233753

Reaktionsgleichung

Reaktionsgleichung von HRID 233753
N1C=CC=CC=1.[C:7]([OH:14])(=[O:13])/[CH:8]=[CH:9]/[C:10]([OH:12])=[O:11].[F:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:23]=[C:24]([CH:28]3[CH2:33][CH2:32][CH2:31][CH2:30][NH:29]3)[CH:25]=[N:26][CH:27]=2)=[CH:18][CH:17]=1>CO>[C:7]([OH:14])(=[O:13])/[CH:8]=[CH:9]/[C:10]([OH:12])=[O:11].[F:15][C:16]1[CH:17]=[CH:18][C:19]([C:22]2[CH:23]=[C:24]([CH:28]3[CH2:33][CH2:32][CH2:31][CH2:30][NH:29]3)[CH:25]=[N:26][CH:27]=2)=[CH:20][CH:21]=1

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 444972Fumaric AcidHCID 196942955-(4-Fluorophenyl)-3-(2-piperidinyl)pyridine

Produkt 1

HCID 196942945-(4-Fluorophenyl)-3-(2-piperidinyl)pyridine fumarateAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The above described pyridine derivative was converted into invention compound of Formula I by the addition of one equivalent of fumaric acid to a methanol (15 mL) solution of the free amine at 25° C. After 30 minutes the solvent was removed in vacuo and the residue pumped under high vacuum. Trituration with diethyl ether resulted in the formation of 5-(4-fluorophenyl)-3-(2-piperidinyl)pyridine fumarate (70%) as a colorless solid. M.p. 209°-210° C. (decomp., Et2O); 1H NMR (DMSO-d6, 300 MHz): δ 8.86 (s, 1 H), 8.63 (s, 1 H), 8.32 (s, 1 H), 7.81 (dd, J=8, 5 Hz, 2 H), 7.32 (app. t, J=8 Hz, 2 H), 6.49 (s, 2 H), 4.24 (dd, J=10, 4 Hz, 1 H), 3.37 (d, J=12 Hz, 1 H), 2.97 (m, 1 H), 1.5-2.1 (m, 6 H).

Aufarbeitung

  1. customAfter 30 minutes the solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-2b69f139f33f49e8a0947ce896de9675
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05594011

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