HCID 53884272, Verbindung → 2-Acetyl-5-t-butoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

HRID 234138Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 234138
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]2[S:14][C:15]([C:17](NCCC3C=CC(OCC(OCC)=O)=C(OCC(OCC)=O)C=3)=[O:18])=[CH:16][C:10]=2[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=C[CH:48]=1>ClCCl>[C:17]([C:15]1[S:14][C:11]2[CH2:12][CH2:13][N:8]([C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[CH2:9][C:10]=2[CH:16]=1)(=[O:18])[CH3:48]

Komponenten

4

Edukt 2

HCID 53884272HCID 53884272, VerbindungHCID 178418287HCID 178418287, Verbindung

Produkt 1

HCID 214659752-Acetyl-5-t-butoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridineAusbeute 191,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To the solution of the compound prepared in (a) (847 mg) in dichloromethane (30 ml) was added Molecular Sieves 4A (3 g), followed by pyridinium chlorochromate (966 mg) under ice-cooling. The mixture was stirred for 40 minutes. After the reaction mixture was filtered through FLORISIL, the filtrate was concentrated to give 772 mg of 2-acetyl-5-t-butoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (yield, 92%).

Aufarbeitung

  1. temperaturecooling
  2. filtrationAfter the reaction mixture was filtered through FLORISIL
  3. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-2ce59e35fdf048fda1e87bc9eb260e69
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05594004

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