4-Chloro-3-methyl-1,2-oxazol-5-amine → HCID 22998496, Verbindung

HRID 234357Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 234357
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Cl:8].[S:9]1[CH:13]=[CH:12][N:11]=[C:10]1[S:14](Cl)(=[O:16])=[O:15]>>[Cl:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:14]([C:10]1[S:9][CH:13]=[CH:12][N:11]=1)(=[O:16])=[O:15]

Komponenten

3

Edukt 2

HCID 105828224-Chloro-3-methyl-1,2-oxazol-5-amineHCID 115792352-Thiazolesulfonyl chloride

Produkt 1

HCID 22998496HCID 22998496, VerbindungAusbeute 33 %

Versuchsvorschrift

N-(4-chloro-3-methyl-5-isoxazolyl)thiazole-2-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-chloro-3-methylisoxazole and thiazole-2-sulfonyl chloride in 33% yield. This was purified by HPLC (5% CH3CN to 100% CH3CN over 30 min.) to give a solid, m.p. 171°-173° C.

Aufarbeitung

  1. customThis was purified by HPLC (5% CH3CN to 100% CH3CN over 30 min.)
  2. customto give a solid, m.p. 171°-173° C.

Quellen und Nachweise

ORD-Eintrag
ord-dc534a28a65b469fac5859058b4c4af3
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05594021

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