HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Iodide → 4-Methyl-1-thiophen-3-yl-pentan-3-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Iodide | HCID 5238 | — |
| Edukt | Triphenylphosphine | HCID 11776 | — |
| Edukt | 3-Bromothiophene | HCID 13383 | — |
| Edukt | 4-Methyl-1-penten-3-ol | HCID 20929 | — |
| Edukt | Sodium Bicarbonate | HCID 516892 | — |
| Katalysator | palladium(II) acetate | HCID 167845 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 4-Methyl-1-thiophen-3-yl-pentan-3-one | HCID 12477279 | — |
Reaktionsschritte
The title compound was prepared according to General Method 4b using 3-bromothiophene (20 mmol), 4-methyl-1-penten-3-ol (30 mmol), sodium iodide (0.7 mmol), sodium bicarbonate (24 mmol), triphenylphosphine (0.6 mmol), DMF (15 mL), and palladium acetate (0.2 mmol). The title compound was flash chromatographed using EtOAc:hexane (5:95 to 10:90).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06852711B2 |
| Quelldatensatz | uspto-grants-2005_02 |
| ORD ID | ord-50673ac04dd24663b8df17cf5ff5776c |
| Quellennotiz | uspto-grants-2005_02 |