Dichloromethane → 5-Chloro-3-(cyclohexylmethyl)-1,3-dihydro-1-(2-methoxy-4-nitrobenzenesulfonyl)-3-(methylamino)indol-2-one

HRID 234524Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 234524
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([CH2:14][CH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[NH:12][CH3:13].[CH3:21][O:22][C:23]1[CH:28]=[C:27]([N+:29]([O-:31])=[O:30])[CH:26]=[CH:25][C:24]=1[S:32](Cl)(=[O:34])=[O:33].C(Cl)Cl>C(Cl)Cl.CCOC(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:32]([C:24]1[CH:25]=[CH:26][C:27]([N+:29]([O-:31])=[O:30])=[CH:28][C:23]=1[O:22][CH3:21])(=[O:33])=[O:34])[C:6](=[O:11])[C:5]2([CH2:14][CH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[NH:12][CH3:13]

Komponenten

5

Edukt 3

HCID 6344DichloromethaneHCID 3094582-Methoxy-4-nitrobenzenesulfonyl chlorideHCID 190765725-Chloro-3-(cyclohexylmethyl)-1,3-dihydro-3-(methylamino)indol-2-one

Produkt 1

HCID 190764665-Chloro-3-(cyclohexylmethyl)-1,3-dihydro-1-(2-methoxy-4-nitrobenzenesulfonyl)-3-(methylamino)indol-2-oneAusbeute 58 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21226138Dichloromethane ethylacetateLösungsmittel

Versuchsvorschrift

This compound is prepared according to the procedure described in EXAMPLE 16 from 1.49 g of 5-chloro-3-(cyclohexylmethyl)-1,3-dihydro-3-(methylamino)indol-2-one and 1.8 g of 2-methoxy-4-nitrobenzenesulfonyl chloride. Chromatography on silica using DCM and then a DCM/AcOEt mixture (95/5; v/v) as the eluent gives 1.5 g of the expected product after crystallization from AcOEt. M.p.=207° C.

Aufarbeitung

  1. customThis compound is prepared

Quellen und Nachweise

ORD-Eintrag
ord-a770969327ed46fc85c7a57d2da872dd
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05594023

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