Triethylamine → HCID 15279352, Verbindung

HRID 234637

Reaktionsgleichung

Reaktionsgleichung von HRID 234637
Cl[C:2]1[C:7]([O:8][CH3:9])=[C:6]([CH2:10][O:11][CH3:12])[N:5]=[CH:4][N:3]=1.[CH:13](=[C:17]1[CH2:22][CH2:21][CH:20]([NH2:23])[CH2:19][CH2:18]1)[CH:14]([CH3:16])[CH3:15].C(N(CC)CC)C>O.C1(C)C=CC=CC=1>[CH:13](=[C:17]1[CH2:18][CH2:19][CH:20]([NH:23][C:2]2[C:7]([O:8][CH3:9])=[C:6]([CH2:10][O:11][CH3:12])[N:5]=[CH:4][N:3]=2)[CH2:21][CH2:22]1)[CH:14]([CH3:16])[CH3:15]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 152793504-Chloro-5-methoxy-6-(methoxymethyl)pyrimidineHCID 15279351HCID 15279351, Verbindung

Produkt 1

HCID 15279352HCID 15279352, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 22272177Toluene waterLösungsmittel

Versuchsvorschrift

3.8 g (20 mmol) of 4-chloro-5-methoxy-6-methoxymethylpyrimidine (DE-A 4 116 089), 3.1 g (20 mmol) of 4-iso-butylidene-cyclohexylamine and 3.0 g (30 mmol) of triethylamine were stirred for 3 hours without solvent at 80°-90° C. After cooling, the mixture was taken up in water/toluene, and the organic phase was dried and evaporated on a rotary evaporator. Purification by chromatography (silica gel/ethyl acetate) gave 2.2 g (36% of theory) of a virtually colorless oil.

Aufarbeitung

  1. temperatureAfter cooling
  2. customthe organic phase was dried
  3. customevaporated on a rotary evaporator
  4. customPurification by chromatography (silica gel/ethyl acetate)
  5. customgave 2.2 g (36% of theory) of a virtually colorless oil

Quellen und Nachweise

ORD-Eintrag
ord-8512c949f59e488294e44de880c15aaa
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05595992

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