Chlorpromazine Hydrochloride → Chlorpromazine

HRID 234882Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 234882
Cl.[Cl:2][C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[N:6]([CH2:17][CH2:18][CH2:19][N:20]([CH3:22])[CH3:21])[C:5]=2[CH:4]=1.[OH-].[Na+]>>[Cl:2][C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[N:6]([CH2:17][CH2:18][CH2:19][N:20]([CH3:21])[CH3:22])[C:5]=2[CH:4]=1

Komponenten

3

Edukt 2

HCID 6240Chlorpromazine HydrochlorideHCID 14798Sodium Hydroxide

Produkt 1

HCID 2726ChlorpromazineAusbeute 98,2 %

Versuchsvorschrift

3.56 g (10 mmol) of 2-chloro-10-(3-dimethylaminopropyl) phenothiazine hydrochloride are suspended in 15 ml of a 1N sodium hydroxide solution. The amine freed is extracted with diethyl ether. The organic phase is decanted and dried over sodium sulfate and then evaporated to dryness to yield 3.13 g of an oil corresponding to the expected product.

Aufarbeitung

  1. extractionThe amine freed is extracted with diethyl ether
  2. customThe organic phase is decanted
  3. dry with materialdried over sodium sulfate
  4. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-8e710455d9a6425c81dc3d577c7506a8
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05597819

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