Trifluoroacetic acid → 4-(Carboxymethyloxy)-4'-cyano-biphenyl

HRID 234979

Reaktionsgleichung

Reaktionsgleichung von HRID 234979
C([O:5][C:6]([CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([C:22]#[N:23])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)=[O:7])(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[C:6]([CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[CH:21]=[CH:20][C:19]([C:22]#[N:23])=[CH:18][CH:17]=2)=[CH:14][CH:15]=1)([OH:7])=[O:5]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 640094Tert-butyl [(4'-cyanobiphenyl-4-yl)oxy]acetate

Produkt 1

HCID 432431004-(Carboxymethyloxy)-4'-cyano-biphenyl

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

32.9 g of 4-(tert.butyloxycarbonylmethyloxy)-4'-cyano-biphenyl dissolved in 250 ml of methylene chloride is mixed slowly with 137 ml of trifluoroacetic acid. After stirring for 3 hours, the reaction mixture is evaporated to dryness and the solid residue is triturated with water.

Aufarbeitung

  1. customthe reaction mixture is evaporated to dryness
  2. customthe solid residue is triturated with water

Quellen und Nachweise

ORD-Eintrag
ord-2647d34b6ed04ee28679791fce90860a
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05597825

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