Sulfuric Acid → 2,4,5-Trifluorobenzamide

HRID 2351027

Reaktionsgleichung

Reaktionsgleichung von HRID 2351027
[F:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([F:11])=[CH:6][C:3]=1[C:4]#[N:5].S(=O)(=O)(O)[OH:13]>>[F:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([F:11])=[CH:6][C:3]=1[C:4]([NH2:5])=[O:13]

Komponenten

3

Edukt 2

HCID 1118Sulfuric AcidHCID 5938132,4,5-Trifluorobenzonitrile

Produkt 1

HCID 27769582,4,5-Trifluorobenzamide

Versuchsvorschrift

In 20 ml of 80% sulfuric acid was dissolved 5.8 g of 2,4,5-trifluorobenzonitrile and the mixture was heated under reflux for 30 minutes. After cooling, the reaction mixture was poured into ice-water and extracted with ethyl acetate. The extract was dried over sodium sulfate and the solvent was removed to yield 5.32 g of 2,4,5-trifluorobenzamide.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 30 minutes
  3. temperatureAfter cooling
  4. extractionextracted with ethyl acetate
  5. dry with materialThe extract was dried over sodium sulfate
  6. customthe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-02bb96cf642d4a6db1a242a2bebdc1e3
Quelldatensatz
uspto-grants-1989_10
Patentnummer
US04871852

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