Dimethylformamide → 5-Ethyl-2-furaldehyde

HRID 235108

Reaktionsgleichung

Reaktionsgleichung von HRID 235108
CN([CH:4]=[O:5])C.O=P(Cl)(Cl)Cl.[CH2:11]([C:13]1[O:14][CH:15]=[CH:16][CH:17]=1)[CH3:12]>>[CH2:11]([C:13]1[O:14][C:15]([CH:4]=[O:5])=[CH:16][CH:17]=1)[CH3:12]

Komponenten

4

Edukt 3

HCID 6228DimethylformamideHCID 185542-EthylfuranHCID 24813Phosphorus oxychloride

Produkt 1

HCID 899895-Ethyl-2-furaldehydeAusbeute 68,9 %

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A sample of DMF (9.3 mL, 120 mmol) was cooled to 0° C. and POCl3 (3.37 g, 22 mmol) was added, the mixture was stirred for 1 hour at 0° C., then 2-ethyl furan (1.92 g, 20 mmol) was added. The reaction was quenched by pouring onto ice, and the mixture was stirred for 18 hours. The mixture was extracted with hexane, which was dried over MgSO4 and concentrated to give 1.71 g of the title compound (used without further purification).

Aufarbeitung

  1. customThe reaction was quenched
  2. additionby pouring onto ice
  3. stirringthe mixture was stirred for 18 hours
  4. extractionThe mixture was extracted with hexane, which
  5. dry with materialwas dried over MgSO4
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-8d178fb4c5434ea987c1f70c41398c35
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05597832

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