Glycine ethyl ester → N-[[2(3-Chlorophenyl)-3H-imidazo[4,5-b]pyridin-3-yl]acetyl]glycine ethyl ester

A solution of 2-(3-chlorophenyl)-3H-imidazo[4,5-b]pyridine-3-acetic acid (9.50 g, 0.033 mole), 1,1'-carbonyldiimidazole (5.35 g, 0.033 mole) and anhydrous tetrahydrofuran (300 ml) was stirred at room temperature for 2 hrs with a stream of nitrogen bubbling through it. To the resulting suspensions was added glycine ethyl ester (8.0 g, 0.078 mole) and the solution stirred over the weekend. The reaction mixture was filtered and the filtrate concentrated in vacuo. The residue was partitioned between ethyl acetate (150 ml) and potassium bicarbonate solution (75 ml). The organic layer was washed with potassium bicarbonate solution (2×50 ml), water (50 ml), brine (25 ml), dried over sodium sulfate, and concentrated in vacuo. The residue (10 g) was recrystallized from tetrahydrofuran-isopropyl ether to give 6.93 g (56%) of an off-white solid, m.p. 144°-145° C.

1. filtrationThe reaction mixture was filtered
2. concentrationthe filtrate concentrated in vacuo
3. customThe residue was partitioned between ethyl acetate (150 ml) and potassium bicarbonate solution (75 ml)
4. washThe organic layer was washed with potassium bicarbonate solution (2×50 ml), water (50 ml), brine (25 ml)
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated in vacuo
7. customThe residue (10 g) was recrystallized from tetrahydrofuran-isopropyl ether

ORD-Eintrag

ord-24f83dc7129d4a179964d8f0a3da6acf

Quelldatensatz

uspto-grants-1989_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04873251