1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one → N-(4-Methoxyphenyl)-4-(pyridin-3-yl)pyrimidin-2-amine

HRID 2352160Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2352160
CN(C)[CH:3]=[CH:4][C:5]([C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)=O.C(=O)(O)O.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][C:27]([NH2:29])=[NH:28])=[CH:22][CH:21]=1>C(O)(C)C>[CH3:18][O:19][C:20]1[CH:21]=[CH:22][C:23]([NH:26][C:27]2[N:29]=[C:5]([C:7]3[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=3)[CH:4]=[CH:3][N:28]=2)=[CH:24][CH:25]=1

Komponenten

4

Edukt 2

HCID 5670331-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-oneHCID 178492308HCID 178492308, Verbindung

Produkt 1

HCID 14346975N-(4-Methoxyphenyl)-4-(pyridin-3-yl)pyrimidin-2-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

A mixture of 14.4 g of 3-dimethylamino-1-(3-pyridinyl)-2-propen-1-one and 16.1 g of 4-methoxyphenyl guanidine carbonate in 200 ml of isopropanol was heated at reflux for 20 hours. The reaction mixture was cooled, the crude product was collected by filtration and washed with water. The material was recrystallized from isopropanol to give the desired product as light yellow crystals, mp 121°-122° C.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 20 hours
  3. temperatureThe reaction mixture was cooled
  4. filtrationthe crude product was collected by filtration
  5. washwashed with water
  6. customThe material was recrystallized from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-06b60842b9e140c999eac6875efd072d
Quelldatensatz
uspto-grants-1989_10
Patentnummer
US04876252

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