3-(Dimethylamino)-1-(2-thienyl)-2-propen-1-one → N-(4-Methoxyphenyl)-4-(2-thienyl)-2-pyrimidinamine

Beteiligte Stoffe

Reaktionsschritte

A mixture of 10.9 g of 3-dimethylamino-1-(2-thienyl)-2-propen-1-one (U.S. Pat. No. 4,374,988) and 11.8 g of 4-methoxyphenylguanidine carbonate in 150 ml of isopropanol was heated at reflux for 48 hours. The solution was cooled, then filtered, giving 9.0 g of the desired product as yellow crystals, mp 158°-160° C.

Herkunft & Nachweise