Methylamine → 1-(2-isopropyloxazol-4-yl)-N-methylmethanamine

HRID 235324

Reaktionsgleichung

Reaktionsgleichung von HRID 235324
[CH3:1][NH2:2].Cl[CH2:4][C:5]1[N:6]=[C:7]([CH:10]([CH3:12])[CH3:11])[O:8][CH:9]=1>O1CCOCC1.O>[CH:10]([C:7]1[O:8][CH:9]=[C:5]([CH2:4][NH:2][CH3:1])[N:6]=1)([CH3:12])[CH3:11]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 27632914-(Chloromethyl)-2-(propan-2-yl)-1,3-oxazole

Produkt 1

HCID 108207841-(2-isopropyloxazol-4-yl)-N-methylmethanamineAusbeute 71 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 218864351,4-Dioxane--water (1/1)Lösungsmittel

Versuchsvorschrift

To 40% aqueous methylamine (100 mL) was added dropwise a suspension of 4-chloromethyl-2-isopropyloxazole (4.20 g, 0.0263 mol) in p-dioxane/H2O (1:1 (v/v), 20 mL) over a 25 min period. After stirring for 45 min at ambient temperature, the volume was reduced to ca. 50 mL by rotary evaporation in vacuo, and NaCl was added. The aqueous was extracted with CHCl3 (4×100 mL), and the combined extract was dried over Na2SO4 and concentrated in vacuo. The resulting brown liquid was chromatographed on a 200 g SiO2 flash column with 2% iPrNH2 /CH2Cl2 followed by a gradient of iPrNH2 /MeOH/CH2Cl2 (0.5:2:97.5, 0.5:4:95.5). Concentration in vacuo of the product-containing fractions afforded the desired compound as a golden oil (2.89 g, 0.0187 mol, 71%): 1H NMR (CDCl3) δ1.33 (d, J=6.9 Hz, 6H), 2.46 (s, 3H), 2.99-3.14 (m, 1H), 3.64 (s, 2H), 7.42 (s, 1H). Mass spectrum: (M+H)+ =155, (M+NH4)+ =172.

Aufarbeitung

  1. customthe volume was reduced to ca. 50 mL by rotary evaporation in vacuo, and NaCl
  2. additionwas added
  3. extractionThe aqueous was extracted with CHCl3 (4×100 mL)
  4. extractionthe combined extract
  5. dry with materialwas dried over Na2SO4
  6. concentrationconcentrated in vacuo
  7. customThe resulting brown liquid was chromatographed on a 200 g SiO2 flash column with 2% iPrNH2 /CH2Cl2
  8. concentrationConcentration in vacuo of the product-containing fractions

Quellen und Nachweise

ORD-Eintrag
ord-ba2659cf562c4bc1a2d50a04362a478e
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05597927

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