Trifluoroacetamidine → HCID 86635440, Verbindung

HRID 2353433Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2353433
[NH2:1][C@H:2]1[C@@H:6]([NH2:7])[CH2:5][N:4]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:3]1.[F:15][C:16]([F:21])([F:20])[C:17](=N)N>C(O)C>[F:15][C:16]([F:21])([F:20])[C:17]1[NH:1][CH:2]2[CH2:3][N:4]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:5][CH:6]2[N:7]=1

Komponenten

4

Edukt 2

HCID 2776882TrifluoroacetamidineHCID 20677776(3R,4S)-rel-1-Boc--3,4-diaMinopyrrolidine

Produkt 1

HCID 86635440HCID 86635440, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To the product from Step C (250 mg) in ethanol (5 mL) was added 2,2,2-trifluoroethanimidamide (180 mg) and the reaction mixture heated to reflux. After 2 h, the mixture was cooled to ambient temperature and the solvent evaporated in vacuo and used without further purification. LC/MS 224.2 (14+1-56).

Aufarbeitung

  1. temperaturethe reaction mixture heated to reflux
  2. customthe solvent evaporated in vacuo
  3. customused without further purification

Quellen und Nachweise

ORD-Eintrag
ord-e9408909e4314dc39c691e1b34b6aad8
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07750034B2

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