Potassium Carbonate → 5-tert-Butyl-2-methoxy-1-methyl-3-nitro-benzene

HRID 2353552Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2353552
[C:1]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([OH:14])=[C:7]([CH3:15])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[C:16]([O-])([O-])=O.[K+].[K+]>CC(C)=O>[C:1]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([O:14][CH3:16])=[C:7]([CH3:15])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 574185474-tert-Butyl-2-methyl-6-nitro-phenol

Produkt 1

HCID 213537455-tert-Butyl-2-methoxy-1-methyl-3-nitro-benzeneAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

4-tert-Butyl-2-methyl-6-nitro-phenol (209 mg, 1 mmol) was dissolved in 3 mL acetone. 552 mg K2CO3 (4 eq) was added, followed by addition of Mel (0.33 mL, 5 mmol). The reaction mixture was stirred vigorously at 60° C. overnight. After removal of the acetone, the residue was shaken with DCM. Filtration and evaporation of the solution yielded 221 mg product which was used as such.

Aufarbeitung

  1. additionfollowed by addition of Mel (0.33 mL, 5 mmol)
  2. customAfter removal of the acetone
  3. stirringthe residue was shaken with DCM
  4. filtrationFiltration and evaporation of the solution

Quellen und Nachweise

ORD-Eintrag
ord-808fd4c818db4aa5a942663546da28f9
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07749999B2

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