Methyl 2,4-dichloropyrimidine-6-carboxylate → methyl 2-chloro-6-[(3S)-3-methylmorpholin-4-yl]pyrimidine-4-carboxylate

Methyl 2,6-dichloropyrimidine-4-carboxylate (5.00 g) was dissolved in DCM (120 mL). (3S)-3-Methylmorpholine (2.49 g) dissolved in triethylamine (3.70 mL) and DCM (10 mL) was added dropwise to the solution over 10 minutes. The reaction was left to stir at room temperature for 1 hour then the mixture concentrated in vacuo and dissolved in DCM (300 mL). The organics were washed with water (150 mL) and dried (MgSO4). The crude material was chromatographed on silica, eluting with 2.5% methanol in DCM, to give the desired compound (3.15 g) as a white solid.

1. waitThe reaction was left
2. concentrationthe mixture concentrated in vacuo
3. dissolutiondissolved in DCM (300 mL)
4. washThe organics were washed with water (150 mL)
5. dry with materialdried (MgSO4)
6. customThe crude material was chromatographed on silica
7. washeluting with 2.5% methanol in DCM

ORD-Eintrag

ord-952bcc14d9a44bd6b9c899bda223d360

Quelldatensatz

uspto-grants-2010_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07750003B2