Triethylamine → N-(4-cyano-3-(trifluromethyl)phenyl)-2-ethoxybenzamide

HRID 2353803Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2353803
[CH2:1]([O:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9](CCCCCCCCCCCCCCC)[C:5]=1[C:6](Cl)=[O:7])[CH3:2].[NH2:28][C:29]1[CH:36]=[CH:35][C:32]([C:33]#[N:34])=[C:31]([C:37]([F:40])([F:39])[F:38])[CH:30]=1.C(N(CC)CC)C>ClCCl>[C:33]([C:32]1[CH:35]=[CH:36][C:29]([NH:28][C:6](=[O:7])[C:5]2[CH:9]=[CH:10][CH:11]=[CH:12][C:4]=2[O:3][CH2:1][CH3:2])=[CH:30][C:31]=1[C:37]([F:38])([F:39])[F:40])#[N:34]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 5221704-Amino-2-(trifluoromethyl)benzonitrileHCID 102500672-ethoxy-6-pentadecyl-benzoyl Chloride

Produkt 1

HCID 68453779N-(4-cyano-3-(trifluromethyl)phenyl)-2-ethoxybenzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2-ethoxy-6-pentadecyl-benzoyl chloride was condensed with 4-Amino-2-trifluoromethyl benzonitrile in dichloromethane in presence of triethylamine as acid scavenger to yield N-(4-Cyano-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide. The reaction mixture was then concentrated in vacuo and the residue was extracted into ethyl acetate. The ethyl acetate layer was washed with water and with cold aqueous hydrochloric acid, then dried over sodium sulphate and finally concentrated in vacuo. The residue obtained was chromatographed over silica gel to afford the desired product.

Quellen und Nachweise

ORD-Eintrag
ord-a62dd58a486e4c698b6b515e224abdc9
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07750047B2

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