1-Ethylpiperazine → HCID 69564789, Verbindung
Reaktionsgleichung
[CH2:1]([N:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)[CH3:2].Cl[C:10]1[CH:11]=[CH:12][C:13]([N+:32]([O-:34])=[O:33])=[C:14]([CH:31]=1)[C:15]([NH:17][C:18]1[CH:23]=[C:22]([C:24]([NH:26][CH:27]2[CH2:29][CH2:28]2)=[O:25])[CH:21]=[CH:20][C:19]=1[CH3:30])=[O:16]>>[CH:27]1([NH:26][C:24]([C:22]2[CH:21]=[CH:20][C:19]([CH3:30])=[C:18]([NH:17][C:15](=[O:16])[C:14]3[CH:31]=[C:10]([N:6]4[CH2:7][CH2:8][N:3]([CH2:1][CH3:2])[CH2:4][CH2:5]4)[CH:11]=[CH:12][C:13]=3[N+:32]([O-:34])=[O:33])[CH:23]=2)=[O:25])[CH2:29][CH2:28]1Komponenten
3
Versuchsvorschrift
Using an analogous procedure to that described paragraph (B) in the portion of Example 1, which is concerned with the preparation of starting materials, N-ethylpiperazine was reacted with 5-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-nitrobenzamide to give N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-5-(4-ethylpiperazine-1-yl)-2-nitrobenzamide; NMR Spectrum: (DMSOd6) 0.57 (m, 2H), 0.67 (m, 2H), 1.02 (t, 3H), 2.30 (s, 3H), 2.37 (m, 2H), 2.48 (m, 4H), 2.83 (m, 1H), 3.49 (m, 4H), 7.06 (m, 2H), 7.28 (d, 1H), 7.56 (d, 1H), 7.96 (s, 1H), 8.04 (d, 1H), 8.35 (d, 1H), 9.91 (s, 1H);
Quellen und Nachweise
- ORD-Eintrag
- ord-df665aa1d2ed4dee98d2ff085905949b
- Quelldatensatz
- uspto-grants-2010_07