Trifluoroacetic acid → HCID 46941286, Verbindung

HRID 2354393Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2354393
[C:1]1([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:6]=[CH:5][C:4]([CH:7]([NH:14][CH3:15])[CH2:8][N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:3][CH:2]=1.[O:22]=[C:23]1[N:28]([CH2:29][C:30]([OH:32])=O)[C:27]2[CH:33]=[C:34]([O:37][C:38]([F:41])([F:40])[F:39])[CH:35]=[CH:36][C:26]=2[O:25][CH2:24]1.C(N(CC)CC)C.F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1.FC(F)(F)C(O)=O>CN(C)C=O.CC#N.O>[C:1]1([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:6]=[CH:5][C:4]([CH:7]([N:14]([CH3:15])[C:30](=[O:32])[CH2:29][N:28]2[C:27]3[CH:33]=[C:34]([O:37][C:38]([F:41])([F:40])[F:39])[CH:35]=[CH:36][C:26]=3[O:25][CH2:24][C:23]2=[O:22])[CH2:8][N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:3][CH:2]=1

Komponenten

8

Edukt 5

HCID 6422Trifluoroacetic acidHCID 8471TriethylamineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 27567161-([1,1'-Biphenyl]-4-yl)-N-methyl-2-(pyrrolidin-1-yl)ethan-1-amineHCID 57488862{3-oxo-6-[(trifluoromethyl)oxy]-2,3-dihydro-4H-1,4-benzoxazin-4-yl}acetic acid

Produkt 1

HCID 46941286HCID 46941286, VerbindungAusbeute 51,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittel2×HCID 18373917Acetonitrile--water (1/1)Lösungsmittel

Versuchsvorschrift

[1-(4-biphenylyl)-2-(1-pyrrolidinyl)ethyl]methylamine (0.087 g, 0.31 mmol) and {3-oxo-6-[(trifluoromethyl)oxy]-2,3-dihydro-4H-1,4-benzoxazin-4-yl}acetic acid (0.1 g, 0.34 mmol) were dissolved in 1 mL of dimethylformamide. Triethylamine (0.13 mL, 0.93 mmol) was delivered to the room temperature mixture, and the solution was allowed to stir for several minutes before a separate solution of 1H-1,2,3-benzotriazol-1-yloxy-tris(dimethylamino)-phosphonium hexafluorophosphate (BOP reagent, 0.150 g, 0.34 mmol) dissolved in 1 mL of dimethylformamide was added at room temperature to the mixture. The reaction was maintained at that temperature for 18 hours, before it was determined to be complete by LCMS (two Aquasil C18, 20×1 mm columns were run in sequence, 4 minutes at 0.1 mL/min, 1-99% CH3CN/H2O with 0.018% trifluoroacetic acid, ES) Rt=2.0 min and m/e 554 [M+1]+. The reaction mixture was filtered through a 0.45 μm PTFE Acrodisk and the crude residue was purified by prep HPLC (Waters, 50×100 mm, 84 mL/min, A: acetonitrile B: water (pH=10, NH4OH), A: 10 to 99% over 15 min, UV detection at 214 nm) to give the title compound (0.087 g. 0.16 mmol, 46%) as an off-white amorphous solid. MS (ES) m/e 554 [M+H]+.

Aufarbeitung

  1. customwas delivered to the room temperature mixture
  2. additionwas added at room temperature to the mixture
  3. temperatureThe reaction was maintained at that temperature for 18 hours, before it
  4. filtrationThe reaction mixture was filtered through a 0.45 μm PTFE Acrodisk
  5. customthe crude residue was purified by prep HPLC (Waters, 50×100 mm, 84 mL/min

Quellen und Nachweise

ORD-Eintrag
ord-2e4c5fe7435a447a850438e84799cf0d
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07749998B2

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