Fluoro(iodo)methane → HCID 11353054, Verbindung
Reaktionsgleichung
[C:1]([C:3]1[CH:4]=[C:5]([C@H:9]([CH2:29][C:30]2[CH:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=2)[C@@H:10]([NH:12][C:13](=[O:28])[C:14]([O:17][C:18]2[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=[CH:20][N:19]=2)([CH3:16])[CH3:15])[CH3:11])[CH:6]=[CH:7][CH:8]=1)#[N:2].[F:37][CH2:38]I>>[C:1]([C:3]1[CH:4]=[C:5]([C@H:9]([CH2:29][C:30]2[CH:35]=[CH:34][C:33]([O:36][CH2:38][F:37])=[CH:32][CH:31]=2)[C@@H:10]([NH:12][C:13](=[O:28])[C:14]([O:17][C:18]2[CH:23]=[C:22]([C:24]([F:27])([F:25])[F:26])[CH:21]=[CH:20][N:19]=2)([CH3:16])[CH3:15])[CH3:11])[CH:6]=[CH:7][CH:8]=1)#[N:2]Komponenten
3
Versuchsvorschrift
N-(1S,2S)-[2-(3-Cyanophenyl)-3-(4-fluoromethoxyphenyl)-1-methylpropyl]-2-(4-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide was prepared from N(1S,2S)-[2-(3-cyanophenyl)-3-(4-hydroxyphenyl)-1-methylpropyl]-2-(4-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide (Example 12, Step B) and fluoromethyliodide following the procedure described in Example 4.
Quellen und Nachweise
- ORD-Eintrag
- ord-e475cc81639e45718a083fdf1bba9298
- Quelldatensatz
- uspto-grants-2010_07