10-Methoxyibogamine → CID 44359441

HRID 2354542

Reaktionsgleichung

Reaktionsgleichung von HRID 2354542
[CH3:1][CH2:2][C@@H:3]1[C@@H:8]2[N:9]3[CH2:11][CH2:12][C:13]4[C:17]5[CH:18]=[C:19]([O:22]C)[CH:20]=[CH:21][C:16]=5[NH:15][C:14]=4[C@@H:7]2[CH2:6][C@@H:5]([CH2:10]3)[CH2:4]1.B(Br)(Br)Br.C(Cl)Cl>>[CH3:1][CH2:2][C@H:3]1[CH:8]2[N:9]3[CH2:11][CH2:12][C:13]4[C:17]5[CH:18]=[C:19]([OH:22])[CH:20]=[CH:21][C:16]=5[NH:15][C:14]=4[C@H:7]2[CH2:6][CH:5]([CH2:10]3)[CH2:4]1

Komponenten

3

Edukt 2

HCID 44210810-Methoxyibogamine2×HCID 22277759Boron tribromide dichloromethane

Produkt 1

HCID 44359441CID 44359441

Versuchsvorschrift

Noribogaine is synthesized by the O-demethylation of ibogaine. This may be accomplished, for example, by reacting ibogaine with boron tribromide/methylene chloride at room temperature and then purifying the product using known procedures. At present, noribogaine may also be obtained from the National Institute on Drug Abuse (Rockville, Md.). The compound has the following structure:

Aufarbeitung

  1. customat room temperature
  2. custompurifying the product

Quellen und Nachweise

ORD-Eintrag
ord-6f7bb93ed4064554b120dcb779f9b613
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07754710B2

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