1-Methyl-3-aminopyrazole → 5-(2-hydroxy-1-methyl-ethoxy)-3-(6-isopropylsulfonylpyridin-3-yloxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Reaktionsgleichung

CO[C:3](=[O:15])[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6](OCOC)[CH:5]=1.Br[C:17]1[CH:18]=[CH:19][C:20]([S:23]([CH:26]([CH3:28])[CH3:27])(=[O:25])=[O:24])=[N:21][CH:22]=1.[O:29]([CH2:37][C@H:38]([OH:40])[CH3:39])[Si](C(C)(C)C)(C)C.[NH2:41][C:42]1[CH:46]=[CH:45][N:44]([CH3:47])[N:43]=1>>[OH:29][CH2:37][CH:38]([CH3:39])[O:40][C:6]1[CH:7]=[C:8]([O:10][C:17]2[CH:22]=[N:21][C:20]([S:23]([CH:26]([CH3:28])[CH3:27])(=[O:25])=[O:24])=[CH:19][CH:18]=2)[CH:9]=[C:4]([CH:5]=1)[C:3]([NH:41][C:42]1[CH:46]=[CH:45][N:44]([CH3:47])[N:43]=1)=[O:15]