Hydrochloric Acid → 3-(4-Fluorophenoxy)pyrrolidine

HRID 2355167Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2355167
Cl.C(OC([N:9]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH2:10]1)=O)(C)(C)C>O1CCOCC1.C(O)C>[F:21][C:18]1[CH:19]=[CH:20][C:15]([O:14][CH:11]2[CH2:12][CH2:13][NH:9][CH2:10]2)=[CH:16][CH:17]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 50999115Tert-butyl 3-(4-fluorophenoxy)pyrrolidine-1-carboxylate

Produkt 1

HCID 218981593-(4-Fluorophenoxy)pyrrolidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

4N hydrogen chloride in dioxane (200 ml) is added to a solution of 3-(4-fluoro-phenoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester 5 (39.43 g, 140 mmol) in ethanol (200 ml) and the mixture stirred at room temperature for 18 hours. The solvent is evaporated under vacuum and the residue basified using 4N sodium hydroxide solution (200 ml). The resulting product is extracted using DCM (3×100 ml). The organic extracts are dried (using MgSO4), filtered and evaporated to give the title compound as a light brown oil.

Aufarbeitung

  1. customThe solvent is evaporated under vacuum
  2. extractionThe resulting product is extracted
  3. dry with materialThe organic extracts are dried (using MgSO4)
  4. filtrationfiltered
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-f74877a49c85405a9d30ffc0c07e2c8b
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07754758B2

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