Sodium Hydroxide → 6-(1-tert-Butoxycarbonyl-piperidin-4-ylamino)-4-trifluoromethyl-nicotinic acid methyl ester

HRID 2355560Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2355560
[CH3:1][O:2][C:3](=[O:15])[C:4]1[C:9]([C:10]([F:13])([F:12])[F:11])=[CH:8][C:7](Cl)=[N:6][CH:5]=1.[C:16]([O:20][C:21]([N:23]1[CH2:28][CH2:27][CH:26]([NH2:29])[CH2:25][CH2:24]1)=[O:22])([CH3:19])([CH3:18])[CH3:17].[OH-].[Na+]>CN(C=O)C>[CH3:1][O:2][C:3](=[O:15])[C:4]1[C:9]([C:10]([F:13])([F:12])[F:11])=[CH:8][C:7]([NH:29][CH:26]2[CH2:25][CH2:24][N:23]([C:21]([O:20][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:22])[CH2:28][CH2:27]2)=[N:6][CH:5]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 12682914-Amino-1-Boc-piperidineHCID 2775340Methyl 6-chloro-4-(trifluoromethyl)nicotinate

Produkt 1

HCID 673987916-(1-tert-Butoxycarbonyl-piperidin-4-ylamino)-4-trifluoromethyl-nicotinic acid methyl esterAusbeute 49 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of 6-chloro-4-trifluoromethyl-nicotinic acid methyl ester (2.00 g, 8.35 mmol, 1.0 equiv; commercially available) and 4-amino-piperidine-1-carboxylic acid tert-butyl ester (2.01 g, 10.02 mmol, 1.2 equiv; commercially available) in anhydrous DMF (10 mL) was heated by microwave irradiation to 110° C. for 4 h. A solution of 1 M NaOH (100 mL) was added and the reaction mixture extracted with ethyl acetate (3×100 mL). The combined organic phases were dried over MgSO4, concentrated by evaporation under reduced pressure and the crude material purified with column chromatography on silica eluting with a gradient of heptane/ethyl acetate (5:1→3:1) to yield 1.65 g (49%) of the title compound. 1H NMR (300 MHz, CDCl3): δ1.36-1.41 (m, 2H), 1.40 (s, 9H), 1.95-1.97 (m, 2H), 2.85-2.93 (m, 2H), 3.81 (s, 3H), 3.92-3.98 (m, 1H), 3.98-4.05 (m, 2H), 5.12 (d, J=8.1 Hz, 1H), 6.59 (s, 1H), 8.68 (s, 1H). 19F NMR (282 MHz, CDCl3): δ−62.38. MS (ISP): 404.5 [M+H]+.

Aufarbeitung

  1. extractionthe reaction mixture extracted with ethyl acetate (3×100 mL)
  2. dry with materialThe combined organic phases were dried over MgSO4
  3. concentrationconcentrated by evaporation under reduced pressure
  4. customthe crude material purified with column chromatography on silica eluting with a gradient of heptane/ethyl acetate (5:1→3:1)

Quellen und Nachweise

ORD-Eintrag
ord-7de2214137624196aca57e22e731defd
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07754744B2

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