1,1'-Carbonyldiimidazole → 1-Benzylimidazolidin-2-one

HRID 23558

Reaktionsgleichung

Reaktionsgleichung von HRID 23558
[CH2:1]([NH:8][CH2:9][CH2:10][NH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:12](N1C=CN=C1)(N1C=CN=C1)=[O:13]>C1(C)C=CC=CC=1>[CH2:1]([N:8]1[CH2:9][CH2:10][NH:11][C:12]1=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 682631,1'-CarbonyldiimidazoleHCID 77801N-Benzylethylenediamine

Produkt 1

HCID 2314031-Benzylimidazolidin-2-oneAusbeute 49,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a solution of N-benzylethylenediamine (6.0 g, 40 mmol) in toluene (50 ml) at 0° C. was added 1,1′-carbonylbis-1H-imidazole (7.8 g, 48 mmol). After stirring the mixture at room temperature overnight, the reaction mixture was washed with water, 5% aqueous citric acid solution and brine. The organic phase was dried over anhydrous magnesium sulfate, filtered and evaporated under reduced pressure. The residue was recrystallized with warm ethyl acetate and filtered off to give 1-benzylimidazolidin-2-one (3.47 g).

Aufarbeitung

  1. washthe reaction mixture was washed with water, 5% aqueous citric acid solution and brine
  2. dry with materialThe organic phase was dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customevaporated under reduced pressure
  5. customThe residue was recrystallized with warm ethyl acetate
  6. filtrationfiltered off

Quellen und Nachweise

ORD-Eintrag
ord-25f7d1db2d0b40efa6b910d5b1689781
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06852744B2

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