Nitric Acid → 6-fluoro-5-nitro-2(3H)-benzoxazolone

HRID 235583Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 235583
[F:1][C:2]1[CH:11]=[CH:10][C:5]2[NH:6][C:7](=[O:9])[O:8][C:4]=2[CH:3]=1.[N+:12]([O-])([OH:14])=[O:13]>S(=O)(=O)(O)O>[F:1][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][C:5]2[NH:6][C:7](=[O:9])[O:8][C:4]=2[CH:3]=1

Komponenten

4

Edukt 2

HCID 944Nitric AcidHCID 144573586-Fluoro-1,3-benzoxazol-2(3H)-one

Produkt 1

HCID 137721116-fluoro-5-nitro-2(3H)-benzoxazoloneAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

A solution of 6-fluoro-2(3H)-benzoxazolone (1.0 g) in 80% aqueous sulfuric acid (6.5 g) was cooled to 0° to 5° C., and 60% nitric acid (0.8 g) was gradually added thereto at 0° to 5° C. The resultant mixture was stirred at the same temperature for 30 minutes and poured onto ice water. The precipitated crystals were collected by filtration, washed with water and dried to give 6-fluoro-5-nitro-2(3H)-benzoxazolone (1.1 g). m.p., 175.4° C.

Aufarbeitung

  1. customat 0° to 5° C
  2. additionpoured onto ice water
  3. filtrationThe precipitated crystals were collected by filtration
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-318e2ce44eb94a15bff3007cbde8da9f
Quelldatensatz
uspto-grants-1987_02
Patentnummer
US04640707

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