1,3-Propanediol → 4-(1,3,2-Dioxaborinan-2-yl)benzoic acid

HRID 2356076Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2356076
[OH:1][B:2]([OH:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.[CH2:13](O)[CH2:14][CH2:15]O>C1(C)C=CC=CC=1>[O:1]1[CH2:15][CH2:14][CH2:13][O:12][B:2]1[C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 104421,3-PropanediolHCID 3121834-Carboxyphenylboronic Acid

Produkt 1

HCID 145278654-(1,3,2-Dioxaborinan-2-yl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A mixture of 4-(dihydroxyboryl)benzoic acid (30.00 g, 181 mmol) and 1,3-propanediol (15.20 g, 200 mmol) in toluene (750 mL) at 140° C. was stirred for 6 hours while collecting the water removed by azeotrope formation. The mixture was concentrated to provide the desired product.

Aufarbeitung

  1. customwhile collecting the water
  2. customremoved by azeotrope formation
  3. concentrationThe mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-8a80a9a9a3624b2cac0e71a14c74c267
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07754886B2

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