Sodium Carbonate → 1-Bromo-2-(bromomethyl)-3,5-dichlorobenzene

HRID 2356654Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2356654
[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[CH2:10]O.P(Br)(Br)[Br:13].C(=O)([O-])[O-].[Na+].[Na+]>ClCCl>[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[CH2:10][Br:13]

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 24614Phosphorus tribromideHCID 14153164(2-Bromo-4,6-dichlorophenyl)methanol

Produkt 1

HCID 104260681-Bromo-2-(bromomethyl)-3,5-dichlorobenzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

3.1 g of the benzyl alcohol 35.4 were dissolved in 40 ml of dry dichloromethane and admixed dropwise at 5° C. with a solution of 0.455 ml of phosphorus tribromide in 10 ml of dichloromethane. The reaction mixture was stirred overnight and then neutralized with 5 ml of a saturated aqueous sodium carbonate solution. The organic phase was removed, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel with n-heptane as the eluent. 2-Bromo-4,6-dichlorobenzyl bromide 35.3 was obtained.

Aufarbeitung

  1. customThe organic phase was removed
  2. dry with materialdried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was purified by column chromatography on silica gel with n-heptane as the eluent

Quellen und Nachweise

ORD-Eintrag
ord-6e293970af944d609abb954eacd082e2
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07759366B2

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