Acrylamide → 3-(Piperidin-1-yl)propanamide

HRID 235670

Reaktionsgleichung

Reaktionsgleichung von HRID 235670
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:7]([NH2:11])(=[O:10])[CH:8]=[CH2:9]>CCO>[O:10]([CH2:6][CH2:5][CH3:4])[CH2:7][CH2:8][CH3:9].[N:1]1([CH2:9][CH2:8][C:7]([NH2:11])=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

5

Edukt 2

HCID 6579AcrylamideHCID 8082Piperidine

Produkt 2

HCID 8114Propyl etherHCID 5667843-(Piperidin-1-yl)propanamideAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of piperidine, 4-(diphenylmethylene) (0.10 mole) and acrylamide (8.95 g, 0.062 mole) in EtOH (50 ml) was refluxed overnight. This reaction mixture was filtered and concentrated. The resulting while solid residue was dissolved in CHCl3, washed with H2O (3×150 ml), dried (Na2SO4) and the solvent removed to give thick yellow oil. Crystallization from CH2Cl2 --i--Pr2O afforded 29.01 g (75%) of 1-piperidinepropanamide, 4-(diphenylmethylene)-; mp 105°-7° C.

Aufarbeitung

  1. filtrationThis reaction mixture was filtered
  2. concentrationconcentrated
  3. dissolutionThe resulting while solid residue was dissolved in CHCl3
  4. washwashed with H2O (3×150 ml)
  5. dry with materialdried (Na2SO4)
  6. customthe solvent removed
  7. customto give thick yellow oil
  8. customCrystallization from CH2Cl2

Quellen und Nachweise

ORD-Eintrag
ord-41cfecc7b47843609ffcb8f699a8479d
Quelldatensatz
uspto-grants-1987_02
Patentnummer
US04640925

Verknüpfte Notizen

Wird geladen…