Cyclohexylamine → HCID 59639572, Verbindung

HRID 2357298Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2357298
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=[C:12](S(C)(=O)=O)[N:13]=2)=[C:4]([CH3:30])[CH:3]=1.[CH:31]1([NH2:37])[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1>>[CH:31]1([NH:37][C:12]2[N:13]=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=3[CH3:30])[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=2)[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1

Komponenten

3

Edukt 2

HCID 7965CyclohexylamineHCID 59639608HCID 59639608, Verbindung

Produkt 1

HCID 59639572HCID 59639572, VerbindungAusbeute 48,1 %

Versuchsvorschrift

Following the general procedure outlined in Example 126, the product of Example 121 (200 mg, 0.47 mmol), and cyclohexylamine (0.27 mL, 2.36 mmol) were reacted to give the crude material, which was purified as described in Example 198 to give the desired product 100 mg (48%). LC-MS: 443.4 (MH+, m/z), 2.79 (Rt, min).

Aufarbeitung

  1. customto give the crude material, which
  2. customwas purified

Quellen und Nachweise

ORD-Eintrag
ord-b3c01bbb9dd944b5912d24f827232d57
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07759486B2

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