Diethyl Carbonate → HCID 68637486, Verbindung

HRID 2357871Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2357871
[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[CH:4][C:3]=1[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].[CH2:16]([O:18][C:19](=O)[O:20]CC)[CH3:17].[H-].[Na+]>C1(C)C=CC=CC=1>[CH2:14]([O:13][C:11](=[O:12])[CH:10]([C:3]1[CH:4]=[C:5]([F:9])[CH:6]=[C:7]([F:8])[C:2]=1[F:1])[C:19]([O:18][CH2:16][CH3:17])=[O:20])[CH3:15]

Komponenten

5

Edukt 3

HCID 7766Diethyl CarbonateHCID 24758Sodium hydrideHCID 53419349Benzoic acid, 2,3,5-trifluoro-, ethyl ester

Produkt 1

HCID 68637486HCID 68637486, VerbindungAusbeute 82,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

Ethyl 2-(2,3,5-trifluorophenyl)-acetate (29 g) was slowly added to a mixture of diethylcarbonate (63 g) and sodium hydride (9.5 g) in toluene (350 ml). After being refluxed for 3 hours, the reaction mixture was cooled, treated with ice-water and washed with water. The organic layer was separated, dried and filtered. The filtrate was concentrated in vacuo to yield 32 g of the title compound.

Aufarbeitung

  1. temperatureAfter being refluxed for 3 hours
  2. temperaturethe reaction mixture was cooled
  3. washwashed with water
  4. customThe organic layer was separated
  5. customdried
  6. filtrationfiltered
  7. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b4adab8be14a42df801d63a3755c957b
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07763622B2

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