4-Bromo-7a-methyl-hexahydro-indene-1,5-dione → 4-Allyloxy-7a-methyl-hexahydro-indene-1,5-dione

HRID 2358270Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2358270
Br[CH:2]1[C:10](=[O:11])[CH2:9][CH2:8][C:7]2([CH3:12])[CH:3]1[CH2:4][CH2:5][C:6]2=[O:13]>C(O)C=C>[CH2:10]([O:11][CH:2]1[C:10](=[O:11])[CH2:9][CH2:8][C:7]2([CH3:12])[CH:3]1[CH2:4][CH2:5][C:6]2=[O:13])[CH:9]=[CH2:8]

Komponenten

3

Edukt 1

HCID 141132994-Bromo-7a-methyl-hexahydro-indene-1,5-dione

Produkt 1

HCID 684575234-Allyloxy-7a-methyl-hexahydro-indene-1,5-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7858Allyl AlcoholLösungsmittel

Versuchsvorschrift

To the stirred suspension of 4-bromo-7a-methyl-hexahydro-indene-1,5-dione 1 (prepared according to the procedure described in J. Org. Chem. 2001, 66, 626.) (2.44 g, 10 mmol), molecular sieves of 4 Å (2.5 g) and silica gel (2.5 g) in allyl alcohol (20 mL) was added Ag2O (2.55 g, 11 mmol) at room temperature. The reaction mixture was stirred at room temperature in the dark for 8 h. The reaction mixture was filtered through a mixture of Celite® and silica gel. The solvent was removed under reduced pressure to yield the title compound as a crude yellow oil.

Aufarbeitung

  1. customprepared
  2. filtrationThe reaction mixture was filtered through a mixture of Celite® and silica gel
  3. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-86f823d3f7ed40d1b438dae46a6f298b
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07763648B2

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