2-Fluoro-5-methylpyridine → 1-(2-Fluoro-5-methylpyridin-3-yl)methanamine

Reaktionsgleichung

[CH2:1]([C:3]1[CH:4]=[C:5]([CH2:10][NH2:11])[C:6]([F:9])=[N:7][CH:8]=1)C.Cl.FC1C=CC(C)=CN=1>>[F:9][C:6]1[C:5]([CH2:10][NH2:11])=[CH:4][C:3]([CH3:1])=[CH:8][N:7]=1

Komponenten

Edukt 2

HCID 27746352-Fluoro-5-methylpyridine

HCID 66732973HCID 66732973, Verbindung

Produkt 1

HCID 534269501-(2-Fluoro-5-methylpyridin-3-yl)methanamine

Versuchsvorschrift

(2-fluoro-5-methylpyridin-3-yl)methanamine (2-e) was prepared by the same synthetic route as that of (2-g) but utilizing the commercially available 2-fluoro-5-methylpyridine (2-c) as a starting material; 1H NMR (500 MHz, DMSO-d6) δ 8.65 (bs, 3 H), 8.07 (d, 1 H, J=1.0 Hz), 8.01 (dd, 1 H, J=15.5, 3.0 Hz), 4.02 (s, 2 H), 2.30 (s, 3 H).

Quellen und Nachweise

ORD-Eintrag: ord-1f07fd99c4a64646af5ccb657b37490f
Quelldatensatz: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07763659B2

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